Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0001p260 | (1) | WCRB2014

In vitro effects of hydrogen peroxide on ALF expression in male mouse germ cells

Habas Khaled S A , Anderson Diana , Brinkworth Martin H

Introduction: ALF is a germ cell-specific counterpart of the large (α/β) subunit of general transcription factor TFIIA and has a vital role in the meiotic and post-meiotic development of male germ cells. We have found in vitro a variety of effects of hydrogen peroxide (H2O2) on different types of germ cells, including the induction of DNA strand breaks and apoptosis. We therefore examined its effect on the expression of genes such as AL...